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Punarnava
Boerhaavia diffusa Linn.

English Name: Spreading hogweed

Family: Nyctaginaceae

Indication
Anti-inflammatory activity of various extracts of roots were studied in carrageenin induced oedema and formaldehyde- induced arthritis in albino rats. Acetone extract showed most potent anti inflammatory effect. Aqueous extract and alkaloid fractions significantly inhibited the increased serum aminotransferase activity in arthritic animals similar to hydrocortisone.

 

 


Liver ATP (adenosine triphosphate), phosphohydrolase activity in arthritic animals was also increased by aqueous extract and the alkaloid. Comparative study for the anti-inflammatory effect of the various parts of the plant in carrageenin induced hindpaw oedema showed that the activity was significantly more in alcoholic extracts of roots and leaves as compared to stem and whole plant. Hypoxanthine-9-L-arabinofuranoside, the nucleoside isolated from the roots showed that like inosine and adenosine, it relaxes the isolated coronary artery of the goat contracted with potassium chloride. The action, similar to that of inosine, is thought to be a direct vasodilator effect, not involving vascular adenosine receptors. The diuretic action of the plant has been shown by various investigators, this effect being significantly higher in water insoluble alcoholic extract of roots and leaves as compared to that of stems and the whole plant.

Fresh juice of leaves is used in dropsy and chronic renal failure in a dose of 20 ml two to three times a day. Roots boiled with milk are used in a single daily dose for maintaining health. Topical use of roots has good anti-inflammatory effect. In a study of 15 patients with nephrotic syndrome treated with the decoction of the crude drug, six responded well, seven improved, while one patient deteriorated.

The plant is well tolerated, though in occasional patients mild laxation is observed.
 




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